According to a study published on Thursday, prescription and nonprescription pain relievers can cause hospitalization for heart failure.
Drugs in question, the so-called NSAIDs, or nonsteroidal anti-inflammatory drugs, including drugs known as COX-2 inhibitors. Many of them are the common drugs to relieve pain and inflammation, and some have been used for decades with minimal security checks.
The close link between the use of NSAIDs and heart failure is well established, but what medicines pose the greatest risk and in what doses, remains poorly understood issue.
To get a clear picture, the team of researchers led by Giovanni Corral Bicocca University in Milan studied the medical records of 10 million people who use NSAIDs in four European countries: Germany, Great Britain, the Netherlands and Italy.
92,163 cases of hospitalization for heart failure were studied to see which of the 27 preparations and in what doses taken. It was found that the current use of NSAIDs slightly increase the risk of hospitalization, compared with the previous use of the nine drugs. These include dikloran, Advil, indomethacin, ketorol, Anaprox, nimesulide, piroxicam and two COX 2 inhibitor, rofecoxib and etoricoxib. In excess doses twice increased likelihood of hospitalization.
Scientists stressed that the study was observational and can not draw accurate conclusions based on it and to identify cause-and-effect relationship.
However, this is further evidence that commonly used drugs NSAIDs and COX2 inhibitors individual associated with an increased risk of hospitalization.
Results of the study were published in BMJ, a medical journal.
"Even a slight increase in the likelihood of heart disease and blood vessels - a problem for modern health care", - stressed Gislason and Torp-Pedersen, experts in cardiac diseases.
One of the drugs, diclofenac is prohibited in any dose by the European Society of Cardiology.
Helen Williams, a consultant pharmacist for cardiovascular diseases of the Royal Pharmaceutical Society of Great Britain, said that the country's National Health Service refuses potent NSAID drugs in recent years. "It is important that the use of most common NSAIDs - ibuprofen - is less risky compared to other drugs," - she added in a commentary published by the scientific press center.
Based on materials medicalxpress.com