New research devoted to the relationship between alcohol consumption and metabolic factors in the prediction of liver diseases. The findings, published in Hepatology, suggest that metabolic syndrome increases the risk of severe liver disease in combination with alcohol consumption.
In the world increases the risk of liver disease, including cancer. Metabolic syndrome and excessive alcohol consumption are associated with an increased risk of liver disease, although only a few patients in the early stages of the disease (eg, fatty liver) develop liver failure or liver cancer . Few studies have examined the metabolic predictors of severe liver complications.
Fredrik Aberg, MD, of the Helsinki University Hospital in Finland and colleagues studied what metabolic factors best predict severe liver complications. Data analysis included 6732 participants without liver disease, who participated in the Finnish Health 2000 study (2000-2001). Researchers analyzed follow-up data on hospitalization, mortality and cancer associated with the liver, from national registries until 2013.
The causes of liver problems were age, female gender, alcohol use, diabetes, cholesterol, and insulin resistance. Among the people who consume large amounts of alcohol, the main cause was diabetes. Among those who drank less alcohol, or did not use at all - it's age, smoking, obesity , cholesterol and insulin resistance.
Dr. Aberg said that alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are treated as separate diseases. This diagnostic approach is that alcohol does not affect the course of NAFLD, and that the metabolic syndrome, a distinctive feature of NAFLD is not a factor in BPO. Research shows that alcohol is a significant risk factor, even though its consumption is in the range, is used to separate NAFLD and ALD.
"The large number of patients with liver disease the effect of alcohol is sometimes impossible to separate the effect of metabolic factors," - says Dr Aberg. For a comprehensive assessment of risk to the liver should simultaneously consider lipid abnormalities, obesity, insulin resistance, diabetes and alcohol consumption.
Dr. Aberg said that liver disease is often detected at later stages. "Our results will help to improve risk assessment for the population as a whole, to the early stages to identify patients who are at high risk for progressive liver disease. Better risk assessment will help to conduct a more intense diagnosis, treatment and monitoring, "- he explains.