A group of researchers from King's College London have discovered a new way to stimulate the recovery of live stem cells in dental pulp using a drug for Alzheimer's disease.
After injury to the internal soft pulp infection gets. To protect against it, there is a thin strip of dentin, which seals the pulp. But this is not enough to restore a large cavity.
For their treatment and filling the holes in the teeth dentists use artificial seal - calcium and silicon. The seal remains in the tooth, and is not destroyed, but the normal mineral levels fully restored.
In an article published today in the scientific reports, scientists at the Dental Institute at King's College London have shown a way to stimulate the stem cells contained in the dental pulp and dentin generate new: this mineralized material which protects the body, potentially reducing the need for fillings.
New biological approach allows you to restore a large cavity, instead of using seals that can carry infection and need to be replaced. When the seal is broken, or there is an infection, dentists remove and fill the affected area. Since the new method stimulates the restoration of the natural tooth, it can eliminate the problem by providing a natural solution for patients.
It is remarkable that one of the small molecules used to stimulate update command stem cells comprises Tideglusib, which was previously used in clinical trials for the treatment of neurological diseases including Alzheimer's disease. This enables an accelerated treatment in practice.
Using biodegradable collagen sponges for transporting drugs team of scientists delivered low doses of a small molecule glycogen synthase kinase (GSK-3) to the tooth. They found that the sponge dissolves over time, and new dentin replaces it, which leads to the full restoration of the natural. Collagen sponges are available in the price and is clinically approved, which is an advantage for use in dental clinics.
The study's author, Professor Paul Sharpe of King's College London, said: "Easy is ideally suited as a clinical dental product for the treatment of large natural cavities, protecting the pulp and dentin regeneration. Use of the drug, which has already been tested in clinical trials for the treatment of Alzheimer's disease, makes it possible to get a quick dental care in clinics. "