Scientists from Tel Aviv University have found an inverse relationship between the known gene that influences the development of cancer and onkopressornoy microRNAs. This dependence is the reason for the survival of patients with cancer of the pancreas ( Learn about the methods of treatment of cancer podzheludonoy in Israel ). The work will help in the creation of drugs for this deadly disease and other cancers.
The study, which was published in Nature Communications, headed by Professor Ronit Satch-Fainaru from Sackler Faculty of Medicine, Hadassah Hyboria and Dr. Shai Eliyahu.
"The life expectancy of patients with pancreatic cancer is low. 75 percent die within a year, and some just After a few months of diagnosis, "- says Professor Sutch-Fainaru.
"But about seven percent live more than five years. We sought to examine what separates the survivors from the other patients, "- continues the professor Satti-Fainaru. "We thought that if we could understand how some people live for several years with this very aggressive disease, we could create a different therapeutic strategy."
The research team examined pancreatic cancer cells and found an inverse relationship between miR-34a, onkoretseptorom and PLK1. Levels of miR-34a were low in pancreatic cancer in mice, whereas the levels of the oncogene were high. This correlation made sense for this type of cancer. But the team had to make sure it is suitable for people.
Molecular profiling revealed the same genomic pattern that has been detected previously in a mouse model of pancreatic cancer.
Scientists have created nanoparticles that selectively delivers genetic material into the tumor does not hurt healthy tissue.
"We have developed delivery nanoastitsy for two passengers: (1) miR-34a, which destroys hundreds of oncogenes, and (2) small interfering RNA PLK1 (siRNA), which silences a gene", - Sutch-Fainaru professor. "They reached the cancerous tissue to change its molecular structure, thereby disarming it and destroying.
"Nanoparticles like a taxi with two important passengers" - continues the professor Satti-Fainaru. "A lot of treatment options - a mixture of drugs, which usually does not reach the tumor simultaneously. But "taxi" kept "passengers", targeting only cancer cells. "
To consolidate the findings, researchers injected new nanoparticles in pancreatic tumors and observed that by balancing these two objectives - bringing them to normal levels by increasing their expression or blocking the gene responsible for the expression thereof, - they significantly prolong the survival of mice.