Immunotherapy of melanoma still has names such as biological therapy or biological response modifier (BRMs). This type of treatment administered in certain cases, and used drugs affect the body's response to a pathology affecting the recognition process by immunomodelirovaniya.
Immunotherapy can be applied:
- For the treatment of advanced melanoma.
- In the adjuvant treatment of high-risk melanoma, including:
- melanoma, which thickness is 4 mm or more;
- melanoma transit metastases;
- positive sentinel lymph nodes;
- affected regional lymph nodes and their recurrence;
- Step IIB, IIC and III;
- local recurrence of melanoma (near the primary tumor).
Medicines and dosage determined by the physician, and depends on the specific characteristics of each case of disease.
Biological preparations for the treatment of melanoma immunotherapy in Israel
The most commonly used drugs in the treatment of melanoma:
- Interferon alfa-2b (Intron A).
- Interferon - a type of protein that is synthesized naturally in the human body to help it fight the infection or oncology. The drug stimulates the immune system to counteract the malignant cells.
- In the adjuvant treatment of melanoma interferon in high doses it can be administered after surgery to reduce the risk of recurrence after complete surgical removal, or if there is a high risk of the disease returning.
- Interferon is used to treat common melanoma.
- BCG (bacillus Calmette-Guerin)
This drug in the treatment of melanoma can be used with a view to local or regional therapy, metastasis, since it is less toxic compared to systemic treatment. The vaccine is administered directly into the tumor.
- Interleukin-2 (Aldesleukin, Proleukin)
For the treatment of transit metastasis or local recurrence in the arm or leg is used Interleukin. Treatment of melanoma immunotherapy in Israel is most effective if administered Interleukin directly to the affected area.
This drug is given as an intravenous infusion for treatment of metastatic or advanced stages of melanoma.
- Ipilimumab (Yervoy)
Ipilimumab is a monoclonal antibody which is used for inoperable or metastatic melanoma. Administered as an infusion.
Side effects in the treatment of melanoma
Negative consequences arise in the treatment of any type of melanoma, but not every patient and to varying degrees. Their appearance may be due to the type of drug, its dosage, and the general state of health of the person.
Side effects may occur at any time, immediately after treatment, after a few days or weeks after the biological treatment, the most recent having a few months or even years. Some of them have become permanent in nature or become permanent. But most of the passes after the end of therapy.
It is important to report the occurrence of negative phenomena team of doctors, which determine their degree of seriousness. In some cases, there is need to adjust immunotherapy for melanoma.
Consider the main side effects. Some people may experience all of the above, no other, there are cases of other negative manifestations.
Flu-like symptoms are frequent side effect of the biological treatment. Chills or fever often occur during the first infusion. These symptoms may occur soon after treatment and include:
- pain in the muscles and joints;
- a sore throat;
- runny nose.
The injection before bedtime, and receive other medications, such as acetaminophen (Tylenol), can help reduce these side effects and improve quality of sleep. Flu symptoms usually disappear during continuation of therapy when the body gets used to the drug. It is necessary to consult a doctor or medical team, if they bother and do not pass.
This manifestation arises due to the fact that immunotherapy for melanoma can affect the cells lining the gastrointestinal tract.
In the process of biological therapy rashes may occur, there is dryness, redness and itching. Get rid of the rash will moisturizer recommended by the attending physician. It is important to protect your skin from UV rays: use sunscreen and wear a hat, long-sleeved shirts and pants.
Fatigue and sleepiness - a common, temporary problems that occur as a result of an immunotherapy for melanoma. The reason is associated with a prescribed dose of the drug, this side effect is often appear in conjunction with influenza-like symptoms.
Nausea and vomiting
Some biological therapy drugs can cause nausea and vomiting in the first few days after treatment. Doctors can prescribe medications before starting therapy to prevent manifestations of data.
Loss of appetite
Nausea and vomiting, fatigue, or accumulation of waste in the body as a result of dying cancer cells often lead to a loss of appetite. This can cause malnutrition and weight loss. Proper nutrition during and after immunotherapy in melanoma will help a person recover from the side effects of treatment.
This symptom is a frequent adverse effect of biological therapy. a team of doctors at the clinic Assuta recommends mild painkillers, such as acetaminophen (Tylenol). About any headache that does not go with medication, or dizziness with headache should inform your doctor.
change in blood pressure
Low pressure - uncirculated side effect of immunotherapy for melanoma. It occurs under the action of certain drugs, such as interleukin-2. It is important to control the pressure, especially at the initial stage of biotherapy. Should get up slowly to prevent dizziness. If it occurs when a person is standing, it is necessary to talk to your doctor.
Highly qualified doctors in the clinic Assuta will ensure the best results of treatment of melanoma, using modern medicine possible.
prices for treatment
The cost of treating melanoma depends on the stage of the disease, select therapies. Consultants Medical Service will send the value of the calculation, it needs to send the documents with the diagnosis. Prices for a number protsedrur presented below:
- Consultation onco-dermatologist - $ 600
- Resection of tumors - 5300 $
- Blood test - from 80 $
- Surgical removal - $ 1900