Chemotherapy in the treatment of ovarian cancer in Israel uses cytotoxic drugs. If the disease is at stage 1C above, chemotherapy is likely to be offered surgery. Cytostatics treatment may be recommended in the early stages, there is high risk of a tumor. In advanced cancer chemotherapy is carried out both before and after surgery. At relapse also used this type of treatment.
There are a number of drugs and chemotherapy regimens in ovarian cancer. one drug or a combination thereof may be appointed. Selection defined earlier stage of cancer and applied cytostatics.
Assuta Medical Complex is the largest network of private clinics in Israel, it employs the best doctors. When choosing chemotherapy should give preference to Assuta Hospital for the following reasons:
- Professional choice of drugs and dosage combinations thereof. Using cell analysis techniques for more accurate selection of treatment.
- The use of the most modern drugs with less toxicity.
- Using a wide variety of ways, reduce side effects.
Some women in this disease is recommended bevacizumab (Avastin) with chemotherapy.
In most cases, ovarian cancer chemotherapy treatment is performed intravenously, is used:
- carboplatin, paclitaxel (Taxol).
Cytotoxic agents are administered vein and they circulate through the bloodstream. Generally, treatment is carried out every three weeks (cycle). Followed by a rest when the body can recover from the adverse effects of chemotherapy in ovarian cancer. Most often it runs six cycles, but may be more.
Each procedure takes 3 to 4 hours in the outpatient department. Therefore, you do not need to stay overnight in the hospital.
Ovarian cancer cytostatics may deliver directly into the abdomen through a catheter.
Physicians often carried intraperitoneal chemotherapy during the initial surgery to remove the cancer. The catheter is connected to a port that delivers the drug into the cavity.
Studies have shown that this type of chemotherapy improves survival. The main drawback is the increased risk of side effects. Sometimes they can be severe enough to stop treatment and go to intravenous drugs.
List of chemotherapy drugs in ovarian cancer:
- Avastin (bevacizumab)
- Clafen (cyclophosphamide)
- Cytoxan (cyclophosphamide)
- doxorubicin hydrochloride
- Dox-SL (Doxorubicin Hydrochloride Liposome)
- Gemcitabine hydrochloride
- Gemzar (Gemcitabine Hydrochloride)
- Hycamtin (Topotecan Hydrochloride)
- Lynparza (Olaparib)
- Olaparib (Olaparib)
- Paraplat (carboplatin)
- Platinol (cisplatin)
- Platinol-AQ (cisplatin)
- Taxol (Paclitaxel)
- Thiotepa (Thiotepa)
- Topotecan hydrochloride
Chemotherapy at relapse
Relapse is called the return of the disease after treatment. In this situation, it uses a series of cytostatic agents. Selection is determined by such factors as:
- an efficacy of previous treatment;
- time interval since the last therapy;
- occurring side effects.
If the disease recurs for more than six months after treatment, the doctor will most likely recommends that carboplatin plus paclitaxel. When it develops in less than six months later, an oncologist can offer the following options:
- paclitaxel as weekly treatment;
Doxorubicin liposomal form - option chemotherapy doxorubicin. Lipid membrane allows more drug to get inside cancer cells and less to harm healthy tissue.
Chemotherapy drugs are selected individually for each case of the disease. For example, topotecan and liposomal doxorubicin can not be assigned to the patient if it is too sick and most of the time in bed. Also topotecan it is not recommended if there is a blockage in the intestines.
Relapse can not be cured, but it is possible to control for many months, sometimes - years.
Possible unwanted effects of chemotherapy in ovarian cancer
All chemotherapy drugs have side effects. Their extent and the amount is determined by specific drugs, dosage, individual response.
All above-mentioned cytostatic agents capable of provoking:
- loss of appetite;
- reduction in the number of blood cells.
Doctors previously in detail tell about the side effects of specific prescription drugs. The patient should immediately report their occurrence doctors because they use many ways to effectively manage side effects.
Sometimes women may feel that chemotherapy lasts a very long time. Especially towards the end of the patient may experience fatigue and difficulty. However, side effects go away gradually, once the treatment is completed.
monitoring of chemotherapy
There are various methods by which a doctor can find out how effective the treatment. Held:
- a blood test for CA125;
- CT or ultrasound.
CA 125 - a protein produced by some ovarian cancer cells. It circulates in the bloodstream. The doctor measures the level of CA 125 before starting treatment. If it's high, the expected result will be a drop in the protein content, since cancer cells will be destroyed by chemotherapy. Thus, the analysis may be carried out before each cycle of chemotherapy or when the treatment is over. The test will show how effective the treatment.
However, not all women with ovarian cancer increased levels of CA 125. If it was not excessive during the initial diagnosis, the blood test can not be used to monitor treatment or during follow-up.
Tumor size can be measured during scanning. The doctor repeats it after completion of therapy to see whether the malignancy decreased.
If the tumor remained after the end of therapy, longer treatment is unlikely to help get rid of it completely. Almost certainly it will grow again, although it may take a long time before there are any symptoms.
In some cases, surgical treatment is used. If the cancer causes symptoms, it can be recommended more than chemotherapy. Some women are prescribed radiation. Option can be treated within clinical trials.
The interaction of chemotherapy drugs in ovarian cancer with supplements
No scientifically validated information about the interaction of cytotoxic drugs with biologically active additives. Some of them may have adverse effects when used simultaneously. Therefore, it is important to inform the doctor about taking any supplements. And if used alternative or complementary therapies.