The term "sarcoma" refers to cancers that develop in the fat, muscle, fibrous, bone tissue in the walls of blood vessels and nerve endings.
The clinic Assuta in the treatment of sarcomas in Israel use advanced technology. Accurate diagnosis competent provides therapeutic process, which is intended to cure the patient, his health improved, longer life. Private medical complex features innovative equipment that can afford to buy on the first throughout the Middle East. Few European clinics can argue with Assuta technical equipment level. In this case, the cost of treatment in an Israeli hospital is lower than in the United States, Germany and other Western countries.
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Turning to us, you insure your interests, get fast, professional and affordable help the best doctors. The official conclusion of the contract guarantees our support at all stages of the service in the hospital. We take care of all the details which may arise abroad - from buying tickets, find the hotel (apartment) to the translation of documentation and support during treatment.
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About the disease:
Basic morphological variants of sarcomas:
- Fibrosarcoma - developing tumor of fibrous tissue;
- Liposarcoma - malignant tumor of adipose tissue;
- Leiomyosarcoma and rhabdomyosarcoma - in muscles;
- Schwannoma - tumor emerging from peripheral nerve membranes;
- Angiosarcoma - tumor in the lymph and blood vessels;
- Synovial sarcoma - tumor of the synovial membranes.
- unclassified sarcoma
Israeli oncologists refer to the following risk factors:
- Hereditary diseases, such as neurofibromatosis.
- Ionizing radiation.
- Chemical compounds (phenols, herbicides, arsenic, asbestos, etc.)
- Human herpes virus (HHV-8).
- Immunosuppressive therapy for transplantation.
- Diseases of the bone (Paget's disease).
Sarcomas develop in various organs. Very often in the soft tissues of the uterus, brain, kidney, stomach, intestines.
Tumor of striated muscle (rhabdomyosarcoma) develops in children. In adults, - sarcomas nerve endings, fat, vascular tissue.
Kaposi give reason to suspect the following signs: growth of soft tissue, bone pain, weight loss, gastrointestinal or uterine bleeding, pain of uncertain location.
Diagnosis of cancer in Israel
Before treatment of sarcoma in Israel is carried out in the diagnosis, one of which - a biopsy:
- Puncture biopsy - fence tumor material is made with a needle;
- Excisional biopsy - removal of the entire tumor with subsequent histological examination;
- In cases where the performance of excision or needle biopsy is not possible, held incisional (cutting) biopsy.
Biopsy techniques make it possible to clarify the morphology of tumor and choose an adequate treatment in Israel. Diagnostics sarcomas includes MRI, X-ray, CT scan, bone scintigraphy. Research helps oncologists clinic Assuta clarify the boundaries, size and spread of malignancy. Based on the results obtained is selected most appropriate method of treatment in Israel.
Sarcoma Treatment in Israel
Sarcoma of soft tissue, although rare, are one of the most difficult tumors. Assuta Medical Center - a specialized clinic, where doctors will assess, accurate diagnosis and develop a treatment plan sarcoma in Israel. Therapy program is tailored to the specific cases and includes a range of different treatments. When selecting therapies take into account such factors as the stage of the disease, the location and size of the tumor, the type of sarcoma, general health, age, personal preferences. May be proposed by techniques such as surgery, radiotherapy, chemotherapy, targeted therapy, participation in clinical trials.
When small, local sarcomas operation is used as the primary method of treating sarcoma in Israel, which will lead to healing. Most likely, that will then be assigned to radiotherapy if the tumor can not be removed in its entirety. Irradiation can help prevent a return of the disease.
If the sarcoma is large, but there are no secondary lesions, radiation therapy may be recommended before surgery or chemotherapy. This treatment of soft tissue sarcoma should reduce the magnitude of the neoplasm. Indications for such therapy are only rabdiosarkoma and Ewing's sarcoma. Other types of sarcomas react poorly to these methods less likely that they will decrease the value. Radiotherapy may be administered postoperatively to destroy malignant preserved segments.
When the swelling extends to the lung or liver, surgery to remove possible secondary foci. It will help to ease the symptoms and keep the cancer under control. cytotoxic drugs can be recommended, radiation or any combination of 3-mentioned methods. Patients with gastrointestinal stromal tumor (GIST) is recommended Targeted therapy with imatinib. If the drug does not work, use another - sunitinib.
Surgery to remove the tumor is the primary treatment for most soft tissue sarcomas. The goal of surgery - resection of the maximum possible volume of the tumor process. Together with sarcoma surgeon removes part of the healthy tissue.
In the past, surgery Kaposi's arm or leg is often meant the removal of the affected limb completely (amputation). But now advances in the surgical treatment allows to reconnect blood vessels (mikrososudistnaya reconstructive surgery). Surgeons may be transferred to the muscles of the operated area from other parts of the body (a muscle flap), to make a skin transplant. All this allows you to avoid amputation in most patients due sparing surgery. Today, less than one in twenty patients diagnosed with sarcoma require amputation. Unfortunately, the size and location of the tumor in the arm or leg may require in some cases radical surgery.
Surgery is used to 1,2,3 step sarcoma. If the operation is too difficult to carry out because of the location of the tumor in the body, radiation therapy instead of surgery may be recommended. For some radiotherapy is contraindicated due to the risk of damage to vital organs.
Many patients radiation therapy is given after surgery to destroy any remaining cell sarcoma, reduce the likelihood of disease return. The need for irradiation depends on the tumor type, size and location. Radiotherapy after surgery is not required in the following cases:
- A tumor of low malignant.
- The value of small tumors.
- The tumor - has not penetrated deep into the tissues.
Sometimes surgery is performed to remove secondary sarcoma lesions, most often - in the lung or liver.
Surgery for metastatic sarcoma
Secondary cancer - when the sarcoma spreads to other parts of the body. Most often the tumor process affects the lungs and sometimes the liver. In some cases it is possible to operate the affected area in these bodies, but as a rule, a small number of people with a limited number of secondary foci. This is an extensive operation, and the doctor will give a detailed explanation for each, individual case.
If the sarcoma was struck by any another area of the body, the doctor is unlikely to offer the operation. Likely to recommend chemotherapy as the drugs circulate throughout the body and treat all affected areas.
When the tumor only in the liver or the lungs, is one of the following methods of treatment of sarcoma in Israel can be applied. All these procedures are aimed at destroying cancer cells without causing excessive bleeding or other side effects. When choosing a doctor will take into account various factors, discuss with the patient the possible benefits and risks of these treatments for soft tissue sarcoma in the given, specific situation.
Hepatic artery chemoembolization in Assuta
This treatment is carried out for secondary sarcoma. Physician, blocking the main artery leading to the liver and blood vessels receiving blood from the liver, introduces chemotherapy with an oily liquid directly into the affected organ.
First, the patient is given a sedative. In the region of a blood vessel in the upper part of the leg the surgeon inserts a local anesthetic under the skin. Under the control of X-rays enters a catheter in a blood vessel leads to the artery, which takes blood from the liver. Reaching the desired zone, the doctor inserts a chemotherapy drug with the oily liquid and removes the catheter.
High doses of cytotoxic agents remain inside sarcoma for several hours. This kills cancer cells, the tumor is reduced. This treatment of sarcoma in Israel takes from 30 minutes to several hours. Then maybe the pain, nausea and fever.
Radiofrequency ablation in Assuta
Radiofrequency ablation using radio waves to destroy cancer cells in the liver or lungs by heating. Basically, patients are given a sedative, but in some cases, general anesthesia is required. If you are using only sedation, local anesthetic is injected into the abdomen or chest. Under CT or ultrasound, the doctor inserts a thin needle through the skin into the center of each tumor. Then the needle is passed through radio waves for heating and destruction of malignancy.
Physicians in the clinic Assuta RFA used to treat soft tissue sarcomas and 5 cm in size. The procedure takes 10-15 minutes. Several hours later, the patient can leave the hospital. You may need retreatment. The main side effects are pain and a high fever for several days.
Radiofrequency surgery Assuta
Radiofrequency surgery uses high frequency radio waves to destroy cancer, like radiofrequency ablation. The surgeon uses ultrasound to visualize the location of the radio-frequency probe. When the probe reaches the desired region, the physician using it destroys the tumor and liver tissue around it. Then surgically remove dead tissue.
The advantage of the treatment of sarcoma in Israel is that heating the tissue directly isolates blood vessels. It marked bleeding in a much lesser extent than in standard operation. However, there is a risk of infection after the procedure.
Cryotherapy in Assuta
Cryotherapy (cryosurgery) involves removal of the tumor by freezing. Indications are secondary sarcoma lesions up to four centimeters. The use of cryotherapy for treatment of soft tissue sarcoma in the lungs is experimental. The procedure takes 30-60 minutes. The operation can be recessed with laparoscopic or general anesthesia using a general or local anesthesia.
The surgeon inserts one or more of the cryoprobe through a small incision in the area of sarcoma under CT or ultrasound. Neoplasm is frozen, can then be given time to thaw and re-freeze. After the procedure, possible pain and fever. They will be appointed analgesics to alleviate the condition. It usually takes a short stay in the ICU, followed by observation.
Microwave ablation in Assuta
This method is used when the secondary foci in the liver or the lungs more than one. Local anesthesia or general anesthesia. The doctor inserts a thin needle into each tumor under CT or ultrasound. Thereafter, the needle attached to a microwave generator. Microwave energy heats and destroys cancer cells.
This method is approved for the treatment of secondary tumors in the liver. No details yet, how microwave ablation is effective for sarcoma in the lungs.
Laser therapy in the treatment of sarcomas in Israel
Laser therapy is called laser ablation. For the destruction of malignant segments surgeon uses a high power beams, heating the fabric to high temperatures. Usually, the patient is given a sedative, but is sometimes used general anesthesia. Through the skin under ultrasound or CT at the center of each tumor catheter with a laser, which heats and destroys them.
Laser therapy is used to treat soft tissue sarcomas and 5 cm. The procedure takes 10-15 minutes. Typically, after a few hours, the patient can leave the hospital. You may have to repeat the treatment. The main side effects include pain and high fever for several days.
Alcohol ablation in Assuta
This treatment for tumors in the liver. To destroy cancer cells using a sterile alcohol. Indications are sarcoma 4-5 cm. The patient is given a sedative, under the skin in the liver region local anesthetic is administered. Under ultrasound or CT administered thin needle in the desired zone, and then enters into the tumor alcohol.
This treatment of soft tissue sarcoma can cause pain, apply effective analgesics. After treatment in the hospital the patient remains a few hours, if there is bleeding or pain. The treatment can be repeated after a while, when the tumors grow quickly.
Radiation therapy uses high energy rays to destroy the abnormal cells. Radiotherapy is performed before or after surgery, or as the main treatment.
Prior to surgery, the goal of radiation therapy is the reduction of the tumor in order to make it easier to resect it. If the treatment of soft tissue tumors such as Kaposi successful, surgery is less extensive.
After surgery to radiotherapy doctors treated to remove from the body any remaining abnormal cells. Irradiation usually begins after 6-12 weeks, when the patient recovers. This treatment of soft tissue sarcoma last for up to 7 weeks. Local time is determined on the basis of type, size and location of the tumor.
Sometimes Radiotherapy is the basic method of treatment of sarcoma in Israel, for example, in the diagnosis - Ewing's sarcoma. But more often it is accessed, when the operation can not be performed due to the location of the tumor, it is too difficult to remove. With radiation therapy, doctors try to control sarcoma, slow down its growth, alleviate symptoms.
Chemotherapyuses anti-cancer (cytotoxic) drugs. Indications for this method are:
- Ewing's sarcoma.
- Embryonal or alveolar rabdiosarkoma.
- Sarcoma in children or young adults.
- Metastatic sarcoma.
It is unknown how effective cytotoxic drugs in certain situations. There is the opportunity to participate in clinical trials. According to several studies, chemotherapy does not help reduce the risk of most types of sarcomas after surgery. Therefore, this method is not standard treatment of sarcoma in Israel after surgery. By the use of chemotherapy is treated individually. Often treated as the tumor is highly malignant with a high risk of relapse.
Chemotherapy drugs enter the body via injection or intravenous. Appointed one drug or a combination thereof.
Chemotherapy treatment of soft tissue sarcoma in some cases, performed before surgery to reduce the magnitude of the neoplasm. It applies a technique called isolated limb perfusion, when the drug is administered only in the arm or leg. This is a complex procedure, which is only available in some medical institutions of Israel, including in the Assuta.
By chemotherapy for soft tissue sarcoma treated to relieve symptoms, to slow progression of the disease, which has spread and recurred. Doctors call this method of palliative therapy.
Biologicals stopped certain chemical reactions that promote cell growth and division. The indications for it are some types of soft tissue sarcomas. Different types of biological therapies have different mechanisms of action - destroy, control or change the behavior of cancer cells. Others - strengthens the immune system, control the symptoms or reduce the side effects of treatment.
Biological therapy used in the treatment of sarcomas in Israel, also called targeted therapy. Targeted drugs target specific molecules, eg, proteins on the surface of cancer cells. These molecules send signals to grow and divide. Targeted drugs stop the development and spread of abnormal cells, causing minimal damage to healthy cells.
The team, working with the patient in the process of planning the treatment of sarcoma in Israel - the choice of drugs, doses and schedules - will take into account the individual characteristics of each case of disease.
Patients with gastrointestinal stromal tumor (GIST) recommend drug called imatinib (Glivec) and Sunitinib (Sutent). Studies have shown that imatinib effectively control the disease for several years.
Votrient (pazopanib) is used for the treatment of metastatic soft tissue sarcoma, which has previously been exposed to chemotherapy.
Sorafenib (Nexavar), sunitinib and bevacizumab (Avastin) used in angiosarcoma.
Bevacizumab and sunitinib is recommended for hemangiopericytoma.
Sirolimus (Rapamune) and everolimus (Afinitor) used in PEComa.
Possible side effects of targeted therapies include:
- vomiting, nausea;
- flu-like symptoms;
- skin rash;
- muscle and joint pain;
- inflammation in the mouth;
- taste changes;
- loss of appetite;
- changes in blood pressure;
- palmar-plantar erythema.
The patient is important to report the occurrence of any side effects, as many of them can be effective to stop, prevent their occurrence.
The cost of treating sarcoma in Israel
sarcoma treatment in Israel takes place individually. Each case is considered a professional doctor who makes a treatment plan. Therapies, each is different, so the price will be calculated specifically for your case. You can see the approximate prices for the services below:
- Oncologist Consultation - $ 600
- Functional examination of the lungs - from $ 800
- PET-CT - 1670 $
- MRI - $ 1470
- Revision of pathology - $ 680
- Biopsy - $ 610
- Removal of the brain tumor by surgery (craniotomy) - $ 34,000
Treatment of sarcoma of the brain is always more expensive than other bodies. This is due to the complexity of operations, the duration of the course of therapy. So that you can accurately know the price of your treatment, send a request at the site Assuta, and we are free to advise you and calculate the cost.
"It all started with the discovery of a lump in the genital area. He was not sick, but well detectable. I thought that the inflamed lymph node, go to the doctor. After scanning became clear testicular tumor. Immediately flew to Israel, took shape in the treatment Assuta. The surgeon cut tumor histology revealed that she has a malignant nature. have I stage of epithelioid sarcoma. Forever remember how Israeli doctors are able to work. There was no feeling that you are in the hospital. Soothe, talk , you are interested in. MN e recommend another surgery to clean up the hazardous area. Then I went through several rounds of radiation therapy. Do not feel any pobochki or complications after radiation. From that moment has passed for 4 years. He's alive, happy, annual screening does not show cancer. "
"I had a problem with his left knee. The pain, arthritis and inflammation, with whom I have fought for several years. The operation on the meniscus. However, this has no effect. Again the pain and swelling. I went to Israel on that tired treated unsuccessfully. On the the time could not walk at all x-rays, MRI found tumors underwent surgery removed it identified inside synovial sarcoma 11 cm -... a rare malignant cancer Fortunately, the cancer has not spread to chose an aggressive type of treatment of 6 cycles of chemotherapy of high dose and radiation .. therapy Medications n Luciano intravenously Each course -. .. 21 days in the hospital have Wi-Fi, which is very convenient, as it allows me to work had multiple blood . transfusions because of the intensive treatment had lost weight, lost hair then beam -... 37 knee treatments here Used been no complications, and alternative methods -. homeopathy, received a special meal my expectations Today, I am healthy to take vitamins, go to the gym , I have overcome the disease ..... Sometimes it was hard, but it was worth it. My team of doctors is very grateful. Helped me get out of this hole called fear. The first year after treatment was observed every six months. Now, once a year going through MRI, CT, analyzes of rent. "