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Genomic approach in the fight against cancer of the intestine

January 19, 2018 16:42

New studies conducted at Queen's University in Belfast, showed how genomics approach to understanding colon cancer (colorectal cancer) will improve the prognosis and quality of life of patients.

For clinicians treating patients with cancer of the intestine is particularly difficult. "Patients with colorectal cancer is offered chemotherapy. Although this treatment may be successful for some patients, for others it does not affect the cancer, and the patients suffer from side effects. A single approach does not work "- said Professor Mark Lawler, senior author of the study.

Scientists at Queen's University in collaboration with Oxford University and the University of Leeds have made progress in the treatment of colon cancer . The study, published in the journal Nature Communications, shows how the definition of gene expression profiles in cells of colon cancer will develop new prognostic markers of cancer and manage individual approaches in medicine.

"By analyzing the genetic and molecular data, we found that there are different subtypes of colorectal cancer. This study will identify specific gene expression profiles that point to the sensitivity or resistance to therapy. Thus, we adapt the treatment to the individual patient, increasing efficacy and minimizing side effects "- scientists say.

Bowel cancer is the fourth common cancer in the UK each year from the disease affects 41,200 people. There are various options for treatment, but mortality rates remain high. colon cancer - the second leading cause of cancer death in the UK.

If the oncologist more is known about the subtype of colon cancer, it is easier to determine whether the treatment will be effective. The discovery of subtypes of this cancer - a serious challenge, since it depends on subsequent therapy.

"We will focus on the fact that the research results are used in practice and become part of the standard approach to patients," - says Tim Mogan, Professor of Clinical Oncology, University of Oxford.

According to Deborah Alsina from the British charity Bowel Cancer Research, the research - the key to new approaches that will improve the results of treatment. When on colon cancer die each year 16 000 people need to understand that the effect of illness, and then to improve and expand the available treatment options.



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