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Researchers are concerned that women rarely make an analysis on the BRCA

15 August 2018 13:26

According to a survey conducted by the American Center of the Vanderbilt-Ingram Cancer, women southeastern states are diagnosed with breast cancer or ovarian cancer did not do a genetic test that would help them and their families to make important decisions about health.

Only 8 per cent of women with disabilities or elderly women insured under the Medicare program and qualifying testing BRCA1 and BRCA2, have made the analysis of the period from 2000 to 2014. The results were published August 14 in JAMA.

In women with breast cancer with pathogenic mutations in BRCA more likely to develop cancer in the other breast, and there is a higher risk of developing ovarian cancer. Their relatives are also at higher risk of developing cancer in the presence of such mutations.

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"Without data on mutations women will not be able to take advantage of preventive therapy, thereby missing an opportunity to reduce the risk of these cancers," - says Amy Gross, an epidemiologist at the Institute of Clinical Research at Vanderbilt.

The study cohort of patients 12 southeastern states included 84,513 participants. Most of them African-Americans (66 percent). Studying medical records and cancer registry data from 49,642 women, Gross determined that in 2002 had been diagnosed with breast cancer, ovarian cancer, or both types of cancer. 718 patients were participants in Medicare insurance programs. The number of patients, which is consistent with Medicare criteria, was 92, but only eight women did a genetic analysis for five years after diagnosis. The researchers were surprised by such a low rate.

In December 2006, Medicare has expanded the criteria for the testing of BRCA1 and BRCA2, but no increase in the number of people to make the analysis. Between the years 2000-2004, none of the 14 women who received the recommendation, did the analysis, in the period from 2005 to 2009, an analysis made only 5 per cent of the 40 women, and between 2010 and 2014 - 15.8 per cent of the 38 women . The reasons can be caused by several factors, including a lack of interest in the patient and the doctor. In a review of medical records indicated that none of the doctors did not register the direction of genetic analysis.

Women identified with the BRCA mutation, should undergo high-risk screening - mammography and MRI of the chest, and some women with mutations even consider bilateral mastectomy to reduce risk. For the treatment of ovarian cancer based on age recommended to remove ovaries and fallopian tubes. Men with BRCA mutations also have an increased risk of prostate cancer and other cancers.



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