A small study suggests that targeted therapy of Hodgkin's lymphoma increases the number of immature eggs in the female ovaries. However, it is too early to talk about improving fertility, as additional tests are needed to better understand the data and the possible consequences.
Researchers from the University of Edinburgh, analyzed samples of ovarian tissue obtained from 14 donors to women undergoing chemotherapy, and 12 healthy women. Initially they wanted to understand why the treatment ABVD chemotherapy drugs does not cause fertility problems in women, in contrast to other forms of chemotherapy.
Scientists have discovered that the ovaries of eight participants, cancer patients who were treated with the help of ABVD, there were a lot more immature oocytes, compared to women's fabrics, which were subjected to other types of chemotherapy, and tissues of healthy study participants.
If subsequent scientific research will be able to determine the mechanism by which ABVD treatment led to an increase in the number of eggs, it will help scientists understand how it is possible to increase the production of eggs throughout a woman's life. Until recently, it was considered impossible.
Scientists are going to continue research to determine the effect of each drug ABVD regime - adriamycin, bleomycin, vinblastine and dacarbazine. They need to find out what the biological mechanisms involved in the production of eggs. Perhaps their findings will help to develop new treatments for infertility and extend the reproductive capacity of women through the replenishment of new ovarian follicles.
The results were published in the «Human Reproduction» magazine with the support of the Medical Research Council.