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Chemotherapy can cause early menopause in young women with lung cancer

29 August 2018 11:51

New research suggests that chemotherapy can cause severe amenorrhea, leading to early menopause in women with lung cancer. Women with lung cancer who wish to give birth in the future, need to be aware of the risks and options before starting treatment. Results of the study are published online in the journal "Menopause" journal "Society of North American Menopause» (NAMS).

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According to the Mayo Clinic, although the diagnosis of lung cancer incidence in men has decreased by 32% since 1975, it has grown by 94% in relation to women and now surpassed breast cancer as the leading cause of cancer death in women in the United States. Although lung cancer is more common in older people, women diagnosed at a younger age than men, and about 5,000 premenopausal women each year are diagnosed with lung cancer in the United States. Extensive studies of women treated for breast cancer, have shown that between 40% and 80% have a premature menopause. However, early indicators of menopause after treatment of lung cancer underestimate.

Unique to the population living in pre-menopausal women, it is a concern that systemic chemotherapy may cause acute amenorrhea and menopause, which leads not only to the tides, vaginal dryness, but also to the possibility of the loss of fertility. Premenopausal women with lung cancer may want children, and should consult with their doctors about the options cryopreservation of embryos and oocytes, the gold standard preservation of fertility.

The study included 182 premenopausal women (mean age of diagnosis - 43 years). Epidemiology and Genetics at the Mayo Clinic lung cancer study examined women between 1999 and 2016 in the diagnosis and annually thereafter of their menstrual status. It was recorded treatments of lung cancer, and have been calculated frequency of self-menopause at each survey.

Results of the study are presented in the article "amenorrhea after treatment of lung cancer." Although the study is small, for the 85 women who received chemotherapy, 64% of respondents reported that they had been menopausal for a year after diagnosis. Only 15% of the 94 patients who did not receive systemic therapy within a year of diagnosis, self-esteem experienced menopause. Three patients received a targeted therapy, two of which were premenopausal at the final inspection. The results show that chemotherapy for patients with lung cancer increases the risk of early loss of menstruation in survivors.

"While the need for more specific research in premenopausal women who need chemotherapy of lung cancer appear to have a similar risk of amenorrhea, early menopause and loss of fertility as women receiving chemotherapy for breast cancer and cancer of lymphoma ," - says Dr. Joanna Pinkerton, executive director of NAMS.



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