Accession curcumin, a component of turmeric to the nanoparticles can be used for targeting and destruction of tumor neuroblastoma cells. This was reported by scientists from the Nemours Children's Hospital and the University of Central Florida, has published the results of a new study in the «Nanoscale».
Neuroblastoma can be resistant to conventional therapy. This study demonstrates a new method of treating tumors without toxic corrosive drugs that cause severe side effects.
Neuroblastoma - a cancer that arises in immature neuronal cells and are usually produced in the adrenal glands, near the kidneys. Every year in the United States are diagnosed 700 cases, and the majority of tumors develop in children younger than 5 years. High-risk neuroblastoma difficult to cure because it often becomes resistant to treatment, or reappears. After the treatment, patients may experience developmental delays, hearing loss and other problems.
It proved that curcumin has antitumor properties, but because of the bad solubility and low stability it difficult to use for medicinal purposes. Now scientists have discovered that it can be delivered to cancer cells using nanoparticles.
Researchers connected cerium oxide nanoparticles and curcumin and dextran covered them to test their effects in cell lines of high-risk neuroblastoma. This caused the death of the tumor cells, but not hurt healthy cells.
A unique approach to targeting cancer cells using nanoparticles may help in the treatment of drug-resistant tumor types. Scientists hope that in the future they will be used for the personalization of patient care and reduce the side effects of therapy.