The function of the heart muscle, as it turns out, is much more complex than previously thought. This is the conclusion reached by experts of the international study, which used data from 73,518 people from around the world to search for new heart genes.
The results were published in the Journal of the American College of Cardiology. This scientific work - an important basis for a new heart research.
The patient's ECG heart helps cardiologists identify muscle abnormalities and organ pulse conduction. These disorders often lead to heart failure and even death. In the study, Dr. Yalda Yamshidi University of London St. George and other experts from 133 research departments compared the ECG of patients with their genetic structure.
According to Dr. Yamshidi, senior lecturer of genetics, it is possible to detect the 52 areas where 67 genes are located, which are involved in the functioning of the heart muscle. Scientists already knew that some of these genes cause serious heart disease, but did not realize that most of them play a role in the functioning of the heart.
Research can serve as a basis for new research projects and ultimately lead to better treatment of heart problems. "The results of scientific research are collected in the library of genes for further research functions of the heart, - explains Dr. Yamshidi. - The next step - to find out what role each gene plays in the body. With this knowledge, we will develop new and better treatments to prevent the disease. "
Experiments on fruit flies
Researchers have already taken the first step, testing the genes in fruit flies. By switching them, they have discovered a gene that is involved in heart development. If this gene is inactive in the fruit fly does not develop heart. Another gene controls the structure of the heart muscle.
Prediction of the course of heart disease
While the development of new drugs based on this large-scale study will take about ten years, patients can use the results in the short term. According to Dr. Yamshidi, studying the genes of patients is becoming a common practice: "By studying the genes we will be able to link them to the risk of cardiac problems. This will allow physicians to use the genetic makeup of a person to predict whether there is a risk of heart failure to consider preventive measures. "
Based on materials medicalxpress.com