Prostate cancer at high risk, which continues to grow, but does not metastasize, usually treated with combination therapy: radiotherapy and hormonal therapy or surgery and radiotherapy. Each method has its advantages and disadvantages, but it is not known which of these methods will be most effective. But the new study found that patient survival above, if the treatment is carried out in combination with radiotherapy of prostate removal.
"Scientists have a lot of debate about whether or not to remove the entire prostate and radiation therapy, or as a second option, do not touch the prostate gland, and conduct radiotherapy and hormone therapy - the researchers noted. - Our results suggest that the removal of the prostate, followed by adjuvant radiotherapy is associated with improved survival of men with prostate cancer. "
Prostate removal risks (prostatectomy) include an increased risk of urinary incontinence and erectile dysfunction. Risks associated with radiation and hormone therapy are less common, and in addition, they are less affected by the quality of life.
"Prostatectomy - is not a popular method of treatment. Our research has shown that removal of the prostate was performed in only 6% of men with high-risk disease. This low percentage was due not only to high risk of side effects, but also the fact that some men are not candidates for surgery for a number of reasons, "- the researchers noted.
The scientists examined the medical records of 13,856 Medicare-man roster SEER.U patients were diagnosed with locally common prostate cancer that has not metastasized to distant organs. Patients were treated both prostatectomy and radiotherapy adjuvant (the first group) as radiotherapy and hormone therapy (second group). The researchers compared the two groups for age, race and comorbidities to control factors that may affect the clinical results, and analyzed the survival rate of patients after 10-15 years after treatment.
They found that after 10 years, 89% of men from the first group and 74% in the second group were still alive, that is the treatment of prostatectomy and radiotherapy had a 15% survival advantage.
Men treatment which consisted of surgery and radiotherapy , have higher rates of erectile dysfunction (29% vs. 20%) and urinary incontinence (49% vs. 19%).
The results of the study were published in «Cancer» magazine.