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The development of malignant melanoma

23 August 2018 15:34

Two new studies have shown how a particular molecule affects the development and function of cells producing antibodies, as well as on how to develop normal melanocytes to malignant melanoma.

"These data on basic immunology and melanoma development come from completely different areas of research, although crossed before," - said Charles Dimitroff, Ph.D., department of dermatology at Brigham and Women's Hospital.

Laboratory Dimitroff, together with the staff of Imperial College London has recently published two articles in the journal Nature Communications, in which the new data on the carbohydrates on the cell surface are detailed ( "glycans"), regulating the function of human B cells and progression of human melanoma - two scientific fields, it seemed I would be at opposite ends of the research spectrum.

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Over the five-year period in the laboratory Dimitroff, Nicholas Giovannone, Ph.D., and Geddes Jenna Sweeney, Ph.D., studied the signs of global glycan human B cells at various stages of differentiation, as well as normal and malignant melanocytes. They found that a great glycan characteristic, known as I-blood group antigens or «I-branch" was central to the glycan-mediated processes that regulate both transmission / activation of human B cells and the aggressiveness of melanoma. Exactly how these features I-branch control the differentiation of B cells and humoral immunity or progression of melanoma when driving, it is still under intense investigation, and, possibly, reveal new targets for immunomodulation or treating cancer.



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