respiration analysis shows potential for noninvasive diagnosis of esophageal cancer, according to a study published online 17 May JAMA in oncology.
Shraz R. Markar, Ph.D., of Imperial College London, and colleagues invited patients to conduct a diagnostic study carried out in three hospitals in London. A total of 335 patients: 172 in the control group and 163 to the non-invasive diagnosis of cancer of the esophagus, who were in the way of treatment. breathing patterns were collected using a protective steel breathing bags and analyzed by mass spectrometry of the ion flow tube.
Sixty-nine percent of patients with non-invasive diagnosis of esophageal cancer were tumor stage T3 / 4, and 65 percent had node metastasis in clinical stage. The researchers found that the characteristic curve of the receiver-operator, obtained by predicting the probabilities generated by the diagnostic model with the five volatile organic compounds had good diagnostic accuracy with an area under the curve of 0.85. For the diagnosis of breathing sensitivity and specificity were respectively 80 and 81 percent.
"The next step is to establish the diagnostic accuracy of the test among patients in primary health care," the authors write.