Despite the concern that hormonal stimulation of the ovaries prior to IVF can increase the risk of ovarian cancer, the researchers were unable to establish any connection between the treatment of infertility and the risk of cancer.
The researchers analyzed the data of each patient, the last IVF between 1994 and 2015, and found that IVF and stimulating hormones are not associated with risk of developing the disease.
Anna Pinborg from the Copenhagen University Hospital presented results of the study, which was attended by 58 572 women who were IVF, and 549 210 women without treatment at the 34th Annual Meeting of the European Society for Human Reproduction and Embryology in Barcelona.
The results showed a higher risk of ovarian cancer among women undergoing treatment. However, the analysis showed higher rates of ovarian cancer in nulliparous women and in patients who have had a reason for female infertility. In contrast, treatment of infertility when the cause of infertility is male partner, is associated with a lower risk of developing cancer.
there has long been concern that drugs to combat infertility, used in IVF, is a risk factor for ovarian cancer, but the biological mechanism is not yet clear. This fear is based on the fact that the increased activity of the ovaries increases the risk. In contrast, pregnancy or use of oral contraceptives that inhibit ovarian activity, reduce risk. Nevertheless, in spite of these assumptions, the increasing age and genetic factors are the most common risk factors.
Demographic study in which we compared data from national cancer registries in Denmark and reproductive health, showed that any excess risk in women was highest in the first two years after treatment, but this excess risk gradually decreased during the study period. "We found that a higher risk of ovarian cancer among women was present only among those with a diagnosis of female infertility - said Pinborg. - We have shown that ovarian stimulation does not increase the risk of ovarian cancer. I would advise women planning IVF, not to stop treatment. Ovarian stimulation itself does not represent any excess risk of ovarian cancer. "