Doctors may be one step closer to finding the most effective treatment for the double virus of cancer in combination with an increase in the natural immune system, according to the first study, researchers from the University of Texas Health Science Center at Houston (UTHealth) and Ohio State University.
"The results of this study are very interesting, because it helps to unravel the complex interplay of yin and yang between the natural anticancer power inherent in our immunity, and external-plus cells that kill cancer, who are appointed as a therapy. This is very important because it shows that virotherapy can be combined with cell therapy, "- said the study Corresponding Balveen Kaur, PhD.
Previous research work has discredited virotherapy combination therapy and externally added NK-cells to natural killer cells of the body, but may be obvious advantages for the fight against cancer - under the condition that a sufficient number of external NK-cell deployed to destroy the tumor and stopping its spread. Subject is disclosed in an article published this week in the Proceedings of the National Academy of Sciences (PNAS).
To reach this conclusion, doctors have developed a mathematical formula that reveals a complex interactive relationship between the viral and NK-cells. Mathematical modeling was able to predict how the virus treated tumor will respond to NK-cell therapy, depending on their number, entered into the tumor. He showed that when the amount of externally administered NK-cells is increased, the ability to fight cancer is enhanced. While own NK-cells of the patient present in smaller quantities, concentrate on cleaning the virus and thus have a negative impact on Virotherapy, limiting the power of cancer, cancer strikes. The theory of these equations was subsequently confirmed in practice experiments on mice with brain tumors , paving the way for further work.
NK-cells are part of the innate immune system, and they play an important role in protecting the body against cancer. The main function of NK-cells is to fight against infections, which means that they attack the virus inoculation. If you add enough additional NK-cells, they may kill more tumor cells.
"Natural NK-cells sense and kill infected cancer cells, thereby purifying the virus, but by adding exogenous NK-cells in sufficient quantities, they can destroy residual tumor", - said Kaur, member of the University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences. "Thus, this is a big step forward, which should create more opportunities for further research and development of clinical trials for the treatment of cancer in humans and animals."