In addition to surgery in the treatment of basal cell cancer has not spread to lymph nodes or to other parts of the body, several methods are used in the clinic Assuta. Some of them are described as types of surgery, because they destroy the tumor in the tissues of the body, nor do they use the scalpel and do not remove the skin segments.
Cryosurgery (cryotherapy), basal cell carcinoma
Cryosurgery is used most often for precancerous lesions such as actinic keratosis and basal cell carcinoma of small size. The physician causes the liquid nitrogen to the tumor, its freezing and killing cancer cells. The procedure can be repeated several times. The healing process takes a month or two, there is a scar treated skin may acquire a lighter shade.
Photodynamic therapy of basal cell carcinoma in Israel
Photodynamic therapy (PDT) is actively used in actinic keratosis. Inthe treatment of basal cell carcinomathe effectiveness of PDT are continuing to study. The therapy uses a special liquid preparation that accumulates in tumor cells within hours or days. In addition, it is converted into another chemical that makes the cells very sensitive to certain types of light. Special light source is directed on the tumor, triggering a chemical reaction that leads to the destruction of pathological tissue.
PDT can cause redness and swelling of the skin in the area where applied. Another possible side effect of photodynamic therapy is that it can make a person's skin is very sensitive to sunlight for some time, so taken precautions to avoid severe burns.
Some drugs can enhance the body's response of the immune system in the fight with cancer.
Imiquimod (Zyclara®) is a cream which is used in the treatment of moderate actinic keratoses and some very early forms of basal cell carcinoma. This is not a chemotherapy drug. It makes the immune system more responsive to the tumor lesion of the skin. Typically imiquimod applied several times a week for several weeks, depending on the specific situation. The drug can cause undesirable skin reactions and flu-like symptoms.
Interferon - an immunomodulatory agent, a group of proteins that are synthesized by the immune system in response to the invading virus. It can be injected directly into the tumor to enhance the immune response. Sometimes interferon is used when surgery is not possible, but it may not be as effective as other treatments for basal cell carcinoma.
Laser surgery is a relatively new approach, applying a beam of laser light to kill cancer cells. This method in some cases is indicated for the treatment of actinic keratosis and superficial basal cell carcinoma forms. At the present time it is not known whether this type of treatment to be as effective as standard therapies, so it is not as widely used.
By this procedure, the doctor gets a small amount of trichloroacetic acid (TCA) or similar chemical substance to the tumor, it destroys abnormal cells within several days. By this approach seek to treat actinic keratosis (precancerous condition).
Chemotherapy basal cell carcinoma in Israel
Chemotherapy uses drugs to kill cancer cells. Apply drugs that act directly on the skin (usually in the form of ointments or lotions).
5-fluorouracil - a drug which is often used in the topical treatment of moderate actinic keratosis, as well as in some forms of basal cell skin cancer. It is usually applied to the skin once or twice a day for several weeks.
When applied directly to the skin of 5-FU kills tumor cells near the skin surface, but it has no effect on disposed in the deep layers of the skin or spread to other organs of the abnormal cells. For this reason, it is used only for precancerous lesions and for some very superficial forms of basal cell carcinoma.
Since the drug is not distributed throughout the body, it does not cause side effects such as systemic chemotherapy. The skin may become red and very sensitive for several weeks. Doctors prescribe drugs that facilitate these manifestations. And 5-FU increases the skin's sensitivity to sunlight, so the treated areas should be protected from the sun, to prevent burns for several weeks.
A very small percentage of people can be called a state deficit of dihydropyrimidine dehydrogenase (DPD deficiency), in which the possible development of toxicity, life-threatening, the application of 5-FU.
Gel comprising diclofenac (Solaraze ®), is sometimes used for the treatment of actinic keratosis. It belongs to the non-steroidal anti-inflammatory drugs (NSAIDs), which include aspirin and ibuprofen. As a rule, Solaraze ® administered twice a day for two or three months. He does not have such serious side effects as that of 5-FU, but more time is required to obtain the expected result.
Ingenol mebutate - a new tool for the treatment of actinic keratosis, its action is faster as compared to other gels. The drug is applied to the skin for two or three days. It can cause undesirable skin reactions, which go away within weeks after starting therapy.