Chemotherapy in the treatment of cancer using cytotoxic drugs. This method is used in some types of soft tissue sarcoma . Chemotherapy benefits while insufficiently clear, as different studies have shown different results. For this reason, a team of doctors at the clinic Assuta , working with the patient, will use his experience and tailored to the particular case of the disease, before recommending this method.
Indications for chemotherapy in soft tissue sarcoma in the Assuta
Chemotherapy may be offered in conjunction with radiation therapy before surgery . This approach facilitates removal of a tumor. Sometimes it is used when the value of tumors greater than 5 cm, the tumor has spread to nearby structure, or it can not be removed surgically.
Chemotherapy is also recommended if the patient has a subtype of sarcoma, which responds well to this treatment. In addition, the possibility of chemotherapy before surgery, if the cancer has spread to other parts of the body.
After surgery, cytotoxic drugs are also used for sarcoma. The task - to destroy the remaining cancer cells, reduce the chance of the disease returning. This method is used if the tumor is highly malignant, deep and large, or sarcoma in the limbs or elsewhere, where the cancer is likely to recur.
Treatment of cytostatic agents is also performed with the aim to ease the pain, to control the symptoms of metastatic sarcomas. Palliative treatment is useful if metastases cause symptoms or rapidly progressing. Also applies if the tumor process can not be deleted.
How is chemotherapy for sarcoma in Assuta?
As a rule, it is a systemic treatment when the drugs travel through the bloodstream, reaching and destroying cancer cells throughout the body. Chemotherapy may be regional, ie It is performed only for a particular area of the body.
In developing the program - the selection of drugs, doses and schemes - a team of doctors, working with the patient, will take into account the peculiarities of the particular case of the disease. Basically drug is administered intravenously in an outpatient setting. Treatment is carried out every 3-4 weeks for 6-12 months, determined by the type of sarcoma and treatment plan.
Chemotherapy for soft tissue sarcoma
The most common chemotherapy in this disease are:
- doxorubicin (adriamycin);
- ifosfamide (IFEX);
- epirubicin (Pharmorubicin);
- gemcitabine (Gemzar);
- dacarbazine (DTIC);
- doxorubicin liposomal form;
- temozolomide (Temodal);
- vinorelbine (Navelbine);
- cisplatin (Platinol AQ);
- docetaxel (Taxotere);
- cyclophosphamide (Cytoxan, Procytox);
- Pazopanib (Votrient).
of chemotherapy regimens for soft-tissue sarcoma:
- doxorubicin and dacarbazine;
- doxorubicin, ifosfamide and mesna (Uromitexan);
- doxorubicin, ifosfamide, dacarbazine and mesna;
- ifosfamide, epirubicin and mesna;
- ifosfamide, etoposide (VePesid, VP-16) and mesna;
- gemcitabine and docetaxel;
- gemcitabine and vinorelbine;
- gemcitabine and dacarbazine;
- vincristine (Oncovin), dactinomycin (Cosmegen, actinomycin-D), and cyclophosphamide.
Chemotherapy for specific types of soft tissue sarcomas
Some types of sarcomas are treated with certain cytotoxic drugs, and combinations thereof.
Rhabdomyosarcoma in adults
- irinotecan (Camptosar);
- topotecan (Hycamtin);
Combinations of chemotherapy for rhabdomyosarcoma in adults:
- vincristine, cyclophosphamide, and dactinomycin;
- vincristine, cyclophosphamide, and doxorubicin;
- vincristine, doxorubicin and cyclophosphamide alternated with ifosfamide and etoposide (VePesid, VP-16);
- vincristine, doxorubicin and ifosfamide;
- cyclophosphamide and topotecan (Hycamtin);
- ifosfamide and doxorubicin;
- ifosfamide and etoposide;
- irinotecan (Camptosar, CPT-11) and vincristine;
- carboplatin (Paraplatin) and etoposide;
- vinorelbine and cyclophosphamide;
- vincristine, irinotecan and temozolomide.
- Paclitaxel (Taxol);
- sorafenib (Nexavar);
- sunitinib (Sutent);
- bevacizumab (Avastin).
- bevacizumab and temozolomide;
Alveolar soft tissue sarcoma
The most common chemotherapy drug - sunitinib.
- sirolimus (Rapamune)
- everolimus (Afinitor)
Side effects of chemotherapy in soft tissue sarcoma
Side effects vary from patient to patient, someone has a lot of unintended consequences, someone - almost none. Their appearance is determined by such factors as the general health of the patient, specific formulations, the dose, the path of drug intake.
Common side effects include the following:
- Vomiting and nausea.
- Loss of appetite, change in taste.
- Inflammation of the oral mucosa.
- Changes in the skin - redness, dryness, itching, or rash, sensitivity to sunlight.
- Bone marrow suppression, low blood counts.
- Damage to the organs - heart, bladder, nervous system.
- Flu-like symptoms.
- Infertility - a decrease in sperm production in men, changes in the menstrual cycle in women.
Most side effects can be managed successfully. It is important that the patient is immediately informed the doctor about symptoms occur.